Description

L-Valine-D8 is a stable isotope-labeled analog of the essential amino acid L-Valine, where eight hydrogen atoms are replaced by deuterium. This high-purity compound is critical for advanced research and analytical applications requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by pharmaceutical, biotechnology, and academic research institutions engaged in mass spectrometry, NMR spectroscopy, and metabolic pathway studies.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous L-Valine levels in biological samples.
• Metabolic Research & Tracer Studies: Used to investigate protein synthesis, amino acid metabolism, and turnover rates in cell cultures, animal models, and human clinical studies.
• Pharmaceutical Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to trace the fate of valine-containing drug compounds.
• NMR Spectroscopy: Acts as a deuterated probe for structural and dynamic studies of proteins and biomolecules without signal interference from protons.
• Nutritional Science Research: Facilitates studies on amino acid absorption, utilization, and requirements in various physiological states.
• Diagnostic Assay Development: Used in the calibration and validation of diagnostic kits and assays targeting amino acid disorders.

Basic Information

Product Name	L-Valine-D8
CAS No.	35045-72-8
Molecular Formula	C5H3D8NO2
Molecular Weight	125.20 g/mol
Synonyms	(2S)-2-Amino-3-methyl(3,3,4,4,5,5,5-d7)butanoic acid; (2S)-2-Amino-3-methylbutanoic-3,3,4,4,5,5,5-d7 acid; L-Valine-d8; Valine-d8; (S)-Valine-d8; Deuterated L-Valine; Perdeuterated L-Valine; L-2-Amino-3-methylbutyric acid-d8
EINECS	Contact for details

Quality Control

Our L-Valine-D8 is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-content), chemical purity (HPLC), chiral purity, and other critical parameters. We support compliance with relevant cGMP and ISO guidelines for research and pharmaceutical use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to prevent moisture uptake and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (D-content)	≥ 98 atom % D
Chiral Purity ([α]D)	≥ 99.0% L-Isomer
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.