Description

4-(Trimethylsilyl)-1H-Pyrazole is a versatile organosilicon-protected pyrazole derivative, a key building block in advanced organic synthesis. Its value lies in the trimethylsilyl (TMS) group, which serves as a protective and directing moiety, enabling precise chemical transformations that are critical for creating complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing pyrazole cores with tailored pharmacokinetic properties.
• Agrochemical Synthesis: Used in the development of modern pesticides, herbicides, and fungicides, where the pyrazole ring contributes to biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized N-heterocyclic ligands used in transition metal catalysis for fine chemical production.
• Material Science Research: Employed in the synthesis of organic semiconductors, metal-organic frameworks (MOFs), and other functional materials requiring precise heterocyclic integration.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to construct biaryl systems, facilitated by the TMS group.
• Protecting Group Strategy: The TMS moiety can be used as a temporary protecting group for the pyrazole nitrogen, allowing selective functionalization at other reactive sites on the molecule.

Basic Information

Product Name	4-(Trimethylsilyl)-1H-Pyrazole
CAS No.	34690-52-3
Molecular Formula	C6H12N2Si
Molecular Weight	140.26 g/mol
Synonyms	1H-Pyrazole, 4-(trimethylsilyl)-; 4-Trimethylsilylpyrazole; 4-(Trimethylsilyl)pyrazole; 4-TMS-Pyrazole; Pyrazole, 4-(trimethylsilyl)-; 4-(Trimethylsilyl)-1H-pyrazole; (4-Pyrazolyl)trimethylsilane; Trimethyl(1H-pyrazol-4-yl)silane
EINECS	Contact for details

Quality Control

Our 4-(Trimethylsilyl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and batch-to-batch consistency for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.