Description

(+)-4-[[(R)-5,6,7,8-Tetrahydro-1,3-Dioxolo[4,5-G]Isoquinoline-5-Yl]Methyl]Phenol is a high-purity chiral chemical intermediate of significant importance in advanced pharmaceutical synthesis. Its complex, fused-ring structure makes it a valuable building block for the development of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel therapeutic agents, particularly for neurological and cardiovascular applications.
• Asymmetric Synthesis: Utilized in the construction of complex molecules requiring high enantiomeric purity due to its defined (R)-configuration.
• Medicinal Chemistry Research: Serves as a key scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-Up: Used in the development and optimization of commercial-scale manufacturing processes for target APIs.
• Reference Standard: Employed as an analytical standard for quality control and method validation in pharmaceutical analysis.
• Fine Chemical Synthesis: Applied in the multi-step synthesis of other specialized, high-value chiral compounds.

Basic Information

Product Name	(+)-4-[[(R)-5,6,7,8-Tetrahydro-1,3-Dioxolo[4,5-G]Isoquinoline-5-Yl]Methyl]Phenol
CAS No.	34168-00-8
Molecular Formula	C19H19NO3
Molecular Weight	309.36 g/mol
Synonyms	(R)-(-)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-methylenedioxyisoquinoline; (R)-1-(4-Hydroxybenzyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline; (R)-1-[(4-Hydroxyphenyl)methyl]-6,7-(methylenedioxy)-1,2,3,4-tetrahydroisoquinoline; (R)-(-)-1-(4-Hydroxybenzyl)-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline; NSC 339579; (R)-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-methylenedioxyisoquinoline
EINECS	Contact for details

Quality Control

Our (+)-4-[[(R)-5,6,7,8-Tetrahydro-1,3-Dioxolo[4,5-G]Isoquinoline-5-Yl]Methyl]Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and ensure product stability. Keep the container in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.