Description

tert-Butyldiphenylsilane is a versatile organosilicon compound widely used as a key intermediate and protecting group reagent in advanced organic synthesis. Its primary value lies in its role as a precursor to tert-butyldiphenylsilyl (TBDPS) chloride, a cornerstone reagent for the selective protection of hydroxyl groups, particularly in complex multi-step syntheses. This makes it an essential material for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where precise molecular construction is critical.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for nucleosides, steroids, and complex natural products.
• Hydroxyl Group Protection: Serves as the starting material for generating TBDPS chloride and other silylating agents used for the robust protection of primary and secondary alcohols during multi-step organic synthesis.
• Agrochemical Synthesis: Employed in the development and production of advanced pesticides, herbicides, and plant growth regulators requiring selective functional group manipulation.
• Material Science Research: Used in the synthesis of novel silicon-containing polymers, dendrimers, and advanced organic electronic materials.
• Process Chemistry & Scale-up: Valued in pilot plant and manufacturing settings for its reliability and well-understood chemistry in large-scale protective group strategies.
• Academic & R&D Laboratories: A staple reagent in synthetic chemistry research for constructing complex molecular architectures, including carbohydrates and peptides.

Basic Information

Product Name	tert-Butyldiphenylsilane
CAS No.	33729-92-9
Molecular Formula	C₁₆H₂₀Si
Molecular Weight	240.42 g/mol
Synonyms	tert-Butyldiphenylsilane; t-Butyldiphenylsilane; TBDPS-H; Di-tert-butylphenylsilane; (tert-Butyl)diphenylsilane; Silane, tert-butyldiphenyl-; 1,1-Dimethylethyl(diphenyl)silane; NSC 169088
EINECS	Contact for details

Quality Control

Our tert-Butyldiphenylsilane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.