Description

4-Trimethylsiloxybenzophenone is a specialized organosilicon derivative of benzophenone, serving as a key intermediate in advanced organic synthesis. Its value lies in its ability to act as a protected form of hydroxybenzophenone, facilitating precise chemical transformations under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing photoactive compounds, UV stabilizers, and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring protected phenolic functionalities.
• UV Absorber / Light Stabilizer Precursor: Used in the production of advanced benzophenone-based UV filters and stabilizers for polymers, coatings, and personal care formulations.
• Organic Synthesis Reagent: Acts as a versatile synthon in palladium-catalyzed cross-coupling reactions and other metal-mediated transformations.
• Material Science Research: Employed in the development of organic semiconductors, photoresists, and other functional materials where controlled photoactivity is required.
• Agrochemical Synthesis: Intermediate in the creation of modern pesticides and herbicides that utilize benzophenone scaffolds for enhanced efficacy and environmental profile.
• Laboratory Chemical: Used in academic and industrial R&D for method development and exploring new synthetic pathways involving silicon-protecting groups.

Basic Information

Product Name	4-Trimethylsiloxybenzophenone
CAS No.	33663-72-8
Molecular Formula	C16H18O2Si
Molecular Weight	270.40 g/mol
Synonyms	4-(Trimethylsilyloxy)benzophenone; Benzophenone, 4-(trimethylsilyloxy)-; 4-Hydroxybenzophenone trimethylsilyl ether; p-Trimethylsiloxybenzophenone; (4-Benzoylphenoxy)trimethylsilane; TMS-protected 4-hydroxybenzophenone; 4-OTMS Benzophenone; p-(Trimethylsiloxy)benzophenone
EINECS	Contact for details

Quality Control

Every batch of 4-Trimethylsiloxybenzophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by HPLC, GC, NMR, and other relevant spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.