Description

Iodomethyl-Cyclopropane is a valuable organoiodine building block featuring a reactive cyclopropane ring. This compound is essential for introducing the cyclopropylmethyl group into target molecules, enabling the synthesis of complex structures with enhanced biological or material properties. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for use in cross-coupling reactions, cycloadditions, and as a key synthon in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing cyclopropane motifs known for metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the cyclopropane ring contributes to biological activity.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialized polymers and advanced organic materials.
• Organic Synthesis Reagent: Employed in key transformations such as nucleophilic substitutions, radical reactions, and transition-metal catalyzed cross-couplings (e.g., Negishi, Kumada).
• Ligand and Catalyst Development: Utilized for constructing complex ligand frameworks for asymmetric catalysis and organometallic chemistry.
• Chemical Biology Probes: Acts as a versatile handle for labeling and modifying biomolecules in probe and conjugate synthesis.

Basic Information

Product Name	Iodomethyl-Cyclopropane
CAS No.	33574-02-6
Molecular Formula	C4H7I
Molecular Weight	182.00 g/mol
Synonyms	(Iodomethyl)cyclopropane; Cyclopropylmethyl iodide; 1-(Iodomethyl)cyclopropane; Cyclopropanemethyl iodide; Iodomethylcyclopropane; Cyclopropyl iodomethane; (Cyclopropylmethyl)iodide; 1-Cyclopropylmethyliodide
EINECS	Contact for details

Quality Control

Our Iodomethyl-Cyclopropane is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, documenting key parameters such as assay, impurity profile, and physical properties. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. Due to its light-sensitive nature and potential volatility, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Specific Gravity (20°C)	1.70 - 1.80
Refractive Index (n20D)	1.540 - 1.560

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.