Description

(-)-4-(1,2-Dihydroxyethyl)-8-Hydroxy-1H-2-Benzopyran-1-One is a high-purity chiral compound belonging to the class of dihydroisocoumarins, characterized by its specific stereochemistry and functional groups. This compound serves as a critical chiral building block and intermediate in the synthesis of complex organic molecules, where its defined stereocenter and hydroxyl functionalities are essential for directing subsequent chemical reactions. It is primarily required by pharmaceutical R&D, fine chemical synthesis, and academic research laboratories for developing active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block in stereoselective synthesis to construct complex molecules with defined chirality for medicinal chemistry.
• Fine Chemical Production: Serves as a precursor in the manufacture of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Biochemical Research: Used in studies exploring enzyme inhibitors, receptor ligands, and other biologically active compounds due to its structural motifs.
• Academic & Industrial R&D: Employed in chemical research for method development, catalysis studies, and the synthesis of natural product analogs.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(-)-4-(1,2-Dihydroxyethyl)-8-Hydroxy-1H-2-Benzopyran-1-One
CAS No.	33547-50-1
Molecular Formula	C11H12O5
Molecular Weight	224.21 g/mol
Synonyms	(-)-4-(1,2-Dihydroxyethyl)-8-hydroxy-1H-isochromen-1-one; (3S)-3,4-Dihydroxy-8-hydroxy-3,4-dihydro-1H-2-benzopyran-1-one; 8-Hydroxy-4-(1,2-dihydroxyethyl)-1H-2-benzopyran-1-one, (-)-; Dihydroisocoumarin derivative; (S)-enantiomer of 4-(1,2-Dihydroxyethyl)-8-hydroxyisocoumarin; 33547-50-1; (-)-form of the dihydroxyethyl hydroxybenzopyranone.
EINECS	Contact for details

Quality Control

Our (-)-4-(1,2-Dihydroxyethyl)-8-Hydroxy-1H-2-Benzopyran-1-One is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. We support compliance with cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.