Description

6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a versatile and high-purity organic salt, serving as a critical synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its role as a key building block for constructing complex nitrogen-containing heterocycles, which are prevalent in active pharmaceutical ingredients (APIs). This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop new therapeutic agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of various bioactive molecules and potential drug candidates targeting the central nervous system.
• Medicinal Chemistry Research: Used as a scaffold for constructing tetrahydroisoquinoline derivatives in structure-activity relationship (SAR) studies and lead optimization.
• Agrochemical Synthesis: Serves as a building block for developing novel pesticides and herbicides with specific biological activity.
• Fine Chemical Production: Employed in the multi-step synthesis of complex specialty chemicals, dyes, and functional materials.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting exploratory organic synthesis.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.

Basic Information

Product Name	6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride
CAS No.	33537-97-2
Molecular Formula	C9H10ClN • HCl
Molecular Weight	204.10 g/mol
Synonyms	6-Chloro-1,2,3,4-tetrahydroisoquinoline HCl; 6-Chloro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 6-Chloro-THIQ hydrochloride; 6-Chloro-1,2,3,4-tetrahydroisoquinolinium chloride; 6-Chloro-3,4-dihydro-1H-isoquinoline hydrochloride; 6-Chloro-3,4-dihydroisoquinoline hydrochloride; 6-Chloro-1,2,3,4-tetrahydro-isoquinoline monohydrochloride
EINECS	Contact for details

Quality Control

Our 6-Chloro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.