Description

6-Methyl-D3-Mercaptopurine is a stable isotope-labeled analog of 6-Methylmercaptopurine, a key metabolite of the immunosuppressant azathioprine. This deuterated compound is specifically designed for use as an internal standard in quantitative bioanalytical methods, ensuring high accuracy and reliability in pharmacokinetic and metabolic studies. It is an essential tool for pharmaceutical researchers and contract research organizations (CROs) engaged in drug development, clinical trials, and forensic toxicology.

Application

• Bioanalytical Internal Standard: Primary use as a deuterated internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the precise quantification of 6-Methylmercaptopurine in biological matrices like plasma, serum, and urine.
• Pharmacokinetic Research: Enables accurate tracking of drug metabolism and clearance rates for azathioprine and related thiopurine drugs in clinical and pre-clinical studies.
• Therapeutic Drug Monitoring (TDM): Critical for developing and validating assays to monitor patient drug levels, optimizing efficacy and minimizing toxicity of immunosuppressive therapies.
• Metabolite Pathway Analysis: Used in research to elucidate and quantify specific metabolic pathways of thiopurine drugs.
• Forensic and Doping Control Analysis: Supports the detection and confirmation of thiopurine drug metabolites in forensic toxicology and anti-doping programs.
• Reference Material for Method Development: Serves as a high-purity certified reference material for calibrating instruments and validating new analytical methods in regulatory environments.

Basic Information

Product Name	6-Methyl-D3-Mercaptopurine
CAS No.	33312-93-5
Molecular Formula	C6H3D3N4S
Molecular Weight	169.20 g/mol
Synonyms	6-(Methyl-d3)mercaptopurine; 6-(Methyl-d3)-1H-purine-6-thiol; 6-(Methyl-d3)-9H-purine-6-thiol; 6-MMP-d3; Deuterated 6-Methylmercaptopurine; 6-Methylmercaptopurine-d3; [2H3]-6-Methylmercaptopurine; Stable Isotope Labeled 6-MMP
EINECS	Contact for details

Quality Control

Our 6-Methyl-D3-Mercaptopurine is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and LC-MS, to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided. We support compliance with GMP/GLP guidelines for research use.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect the hygroscopic and light-sensitive material.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.