Description

2-Amino-5-Fluorobenzenethiol is a versatile aromatic thiol and aniline derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a nucleophilic thiol (-SH) and an amino (-NH2) group, makes it an indispensable intermediate for constructing complex heterocyclic and pharmaceutical scaffolds. This compound is primarily sought by research and development chemists, process engineers, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated benzothiazole, benzimidazole, and thiazolo[5,4-d]pyrimidine derivatives, which are core structures in various drug discovery programs.
• Agrochemical Synthesis: Used to develop novel fungicides, herbicides, and plant growth regulators that incorporate the fluorinated benzothiol motif for enhanced bioactivity and stability.
• Ligand and Catalyst Preparation: Serves as a chelating agent for metal complexes in catalysis and as a building block for functionalized ligands used in asymmetric synthesis.
• Material Science: Employed in the production of specialty polymers, dyes, and pigments where the fluorine and sulfur atoms impart unique electronic and physical properties.
• Chemical Research: A valuable reagent for studying nucleophilic aromatic substitution reactions and for introducing sulfur-containing functional groups into complex molecules.

Basic Information

Product Name	2-Amino-5-Fluorobenzenethiol
CAS No.	33264-82-3
Molecular Formula	C6H6FNS
Molecular Weight	143.18 g/mol
Synonyms	5-Fluoro-2-aminobenzenethiol; 2-Amino-5-fluorothiophenol; 5-Fluoro-2-mercaptoaniline; 2-Mercapto-5-fluoroaniline; Benzenethiol, 2-amino-5-fluoro-; 2-Amino-5-fluorophenyl mercaptan; 5-Fluoro-o-aminothiophenol
EINECS	Contact for details

Quality Control

Our 2-Amino-5-Fluorobenzenethiol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results for purity, appearance, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place at 2-8°C or as specified on the label or COA. Due to its sensitivity to oxidation and light, prolonged exposure to air and ambient conditions should be avoided.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.