Description

5-Acetylthiophene-3-Carboxylic Acid is a high-purity, multifunctional heterocyclic building block essential for advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce both acetyl and carboxylic acid functionalities onto a thiophene scaffold.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the thiophene core contributes to biological activity.
• Material Science Research: Serves as a monomer or functionalizing agent for creating conductive polymers, organic semiconductors, and advanced organic frameworks (MOFs/COFs).
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research and diagnostic applications.
• Ligand Synthesis for Catalysis: The carboxylic acid group allows for the creation of novel ligands used in transition metal catalysis for asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical market.

Basic Information

Product Name	5-Acetylthiophene-3-Carboxylic Acid
CAS No.	33148-86-6
Molecular Formula	C7H6O3S
Molecular Weight	170.19 g/mol
Synonyms	3-Acetyl-5-thiophenecarboxylic Acid; 5-Acetyl-3-thiophenecarboxylic Acid; 3-Carboxy-5-acetylthiophene; 5-Acetylthiophene-3-carboxylic acid; 1-(3-Carboxythiophen-5-yl)ethanone; 5-Acetyl-3-thiophene carboxylic acid; Thiophene-3-carboxylic acid, 5-acetyl-
EINECS	Contact for details

Quality Control

Every batch of 5-Acetylthiophene-3-Carboxylic Acid is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.