Description

4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-6β-Ol Acetate is a high-purity synthetic organic compound belonging to the morphinan class, identified by CAS number 33049-64-8. This compound is of significant interest in advanced pharmaceutical research and development, particularly for its role as a key intermediate or reference standard. It is essential for organizations requiring precise, reliable, and consistent chemical building blocks for complex synthesis. The primary demand for this material comes from the pharmaceutical, analytical, and life science research sectors.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of specialized active pharmaceutical ingredients (APIs) within the opioid or morphinan derivative class.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Biochemical Research: Employed in academic and industrial research to study receptor binding, metabolic pathways, and structure-activity relationships (SAR).
• Process Development: Utilized in scaling up and optimizing synthetic routes for new chemical entities (NCEs) in pilot plants and R&D facilities.
• Impurity Standard: Acts as a characterized impurity standard to monitor and control the quality of related pharmaceutical products during manufacturing.

Basic Information

Product Name	4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-6β-Ol Acetate
CAS No.	33049-64-8
Molecular Formula	C21H27NO5
Molecular Weight	373.45 g/mol
Synonyms	6β-Hydroxy-4,5α-epoxy-3-methoxy-17-methylmorphinan acetate; 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6β-ol acetate ester; 6β-Acetoxy-4,5α-epoxy-3-methoxy-17-methylmorphinan; O6-Acetyl-4,5α-epoxy-3-methoxy-17-methylmorphinan-6β-ol; Noroxymorphone 6β-acetate derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 4,5α-Epoxy-3-Methoxy-17-Methylmorphinan-6β-Ol Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets exacting standards for research and development use. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.