Description

4,5α-Epoxy-3,6-Dimethoxy-17-Methylmorphinan CAS NO 33049-61-5 is a high-purity, specialized morphinan derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate or reference standard in the synthesis and analytical profiling of complex active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions, analytical laboratories, and pharmaceutical manufacturers engaged in the development of novel therapeutic agents within the central nervous system (CNS) and analgesic domains.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex opioid and morphinan-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) in HPLC, GC-MS, and other chromatographic analyses within pharmaceutical QC labs.
• Research & Development: Essential for medicinal chemistry research, structure-activity relationship (SAR) studies, and the discovery of new pharmacologically active compounds.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand drug metabolism and identify potential metabolites.
• Impurity Profiling: Serves as a known impurity or degradation product standard to ensure the purity and safety of final drug substances.

Basic Information

Product Name	4,5α-Epoxy-3,6-Dimethoxy-17-Methylmorphinan
CAS No.	33049-61-5
Molecular Formula	C19H25NO3
Molecular Weight	315.41 g/mol
Synonyms	3,6-Dimethoxy-4,5α-epoxy-17-methylmorphinan; 17-Methyl-4,5α-epoxy-3,6-dimethoxymorphinan; 4,5α-Epoxy-3,6-dimethoxy-17-methylmorphinan; Thebaine derivative; Morphinan-6-ol, 4,5-epoxy-3,6-dimethoxy-17-methyl-, (5α)-; A key thebaine analog.
EINECS	Contact for details

Quality Control

Our 4,5α-Epoxy-3,6-Dimethoxy-17-Methylmorphinan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity assay by HPLC, and control of related substances, to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.