Description

(+)-1-[[(8Ar)-1,2,3,5,6,8A-Hexahydroindolizine]-8-Yl]-1-Butanone is a high-purity, chiral indolizidine alkaloid derivative of significant interest in advanced organic synthesis. This compound serves as a critical versatile chiral building block and key intermediate for the development of complex bioactive molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly within medicinal chemistry and asymmetric synthesis programs.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates, especially those targeting neurological and biological pathways.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material for constructing complex, enantiomerically pure molecules.
• Chemical Biology Probes: Useful for developing molecular probes to study enzyme function and biological mechanisms.
• Academic & Industrial R&D: Serves as a reference standard and a valuable reagent for novel synthetic methodology development.

Basic Information

Product Name	(+)-1-[[(8Ar)-1,2,3,5,6,8A-Hexahydroindolizine]-8-Yl]-1-Butanone
CAS No.	33023-01-7
Molecular Formula	C12H19NO
Molecular Weight	193.29 g/mol
Synonyms	(+)-1-[(8aR)-Octahydroindolizin-8-yl]butan-1-one; (8aR)-1-(1-Butanoyl)octahydroindolizine; (R)-1-(Octahydroindolizin-8-yl)butan-1-one; 1-[(8aR)-1,2,3,5,6,8a-Hexahydroindolizin-8-yl]-1-butanone; (8aR)-Octahydroindolizin-8-yl butyl ketone; (R)-Octahydroindolizin-8-yl butyl ketone; Chiral Indolizidine Butanone Derivative
EINECS	Contact for details

Quality Control

Our production of (+)-1-[[(8Ar)-1,2,3,5,6,8A-Hexahydroindolizine]-8-Yl]-1-Butanone adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing results from HPLC, chiral analysis, NMR, and other relevant tests are provided to guarantee traceability and support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). For long-term storage, consider keeping the material under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.