Description

5-Isoquinolinol, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-1,2-Dimethyl-, (S)- is a chiral, substituted tetrahydroisoquinoline derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated pharmacological intermediate and a versatile building block for constructing complex molecular architectures. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets and alkaloid-based therapeutics.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of novel therapeutic agents, particularly for neurological and cardiovascular applications.
• Asymmetric Synthesis: Utilized as a building block in stereoselective reactions to create complex, biologically active molecules.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Alkaloid Analog Production: Used in the semi-synthesis or total synthesis of tetrahydroisoquinoline alkaloids and their analogs.
• Chemical Biology Probes: Acts as a starting material for developing enzyme inhibitors or receptor ligands used in biochemical assays.
• Academic Research: Employed in university and institutional labs for methodological development in organic and heterocyclic chemistry.

Basic Information

Item	Details
Product Name	5-Isoquinolinol, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-1,2-Dimethyl-, (S)-
CAS No.	32829-58-6
Molecular Formula	C₁₃H₁₉NO₃
Molecular Weight	237.29 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-1,2-dimethyl-5-isoquinolinol; (S)-1,2-Dimethyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-5-ol; (S)-THIQ derivative; (S)-6,7-Dimethoxy-1,2-dimethyl-1,2,3,4-tetrahydro-5-isoquinolinol; (S)-5-Hydroxy-6,7-dimethoxy-1,2-dimethyl-1,2,3,4-tetrahydroisoquinoline; Light-sensitive Tetrahydroisoquinoline Alkaloid Intermediate
EINECS	Contact for details

Quality Control

Our 5-Isoquinolinol, 1,2,3,4-Tetrahydro-6,7-Dimethoxy-1,2-Dimethyl-, (S)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for chiral purity and chemical assay, to ensure compliance with exacting research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (S-enantiomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.