Description

2-Chloro-2-Methylpropane-2-13C is a stable isotope-labeled analog of tert-butyl chloride, where the central carbon atom is enriched with carbon-13. This compound is essential for advanced analytical and research applications, providing a critical internal standard for precise quantification and mechanistic studies using techniques like mass spectrometry and NMR. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, agrochemical, and environmental science sectors for method development, metabolic pathway tracing, and ensuring analytical accuracy.

Application

• Internal Standard for Mass Spectrometry (MS): Serves as a critical reference compound for the accurate quantification of tert-butyl chloride and related compounds in GC-MS and LC-MS analyses.
• NMR Spectroscopy Studies: Used as a carbon-13 labeled tracer to elucidate reaction mechanisms, study molecular structures, and investigate kinetic isotope effects.
• Pharmaceutical Research & Development: Employed in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of chemical moieties derived from the tert-butyl group.
• Environmental Analysis: Acts as a labeled standard for detecting and quantifying volatile organic compounds (VOCs) like tert-butyl chloride in environmental samples.
• Organic Synthesis Intermediate: Functions as a labeled building block for the synthesis of more complex carbon-13 labeled specialty chemicals and fine chemicals.
• Quality Control & Method Validation: Essential for developing and validating highly accurate analytical methods in compliance with regulatory standards (e.g., FDA, EMA).

Basic Information

Product Name	2-Chloro-2-Methylpropane-2-13C
CAS No.	32488-42-9
Molecular Formula	C13CH3C(CH3)2Cl
Molecular Weight	93.57 g/mol (approx.)
Synonyms	tert-Butyl-2-13C chloride; (2-13C)-2-Chloro-2-methylpropane; 1,1-Dimethylethyl-2-13C chloride; 2-Methyl-2-chloropropane-2-13C; Chlorotrimethyl-2-13C methane; Trimethyl-2-13C chloromethane; t-Butyl-2-13C chloride; 13C Labeled tert-Butyl chloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-2-Methylpropane-2-13C is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high chemical and isotopic purity, meeting the exacting requirements for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile and hygroscopic nature, the container must be kept tightly sealed when not in use to prevent moisture absorption and evaporation. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.