Description

2-Bromo-3-Fluorothiophene is a high-purity halogenated thiophene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and fluorine substituents on the thiophene ring, makes it an exceptionally versatile intermediate for introducing specific functionalities into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated thiophene motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental persistence.
• Organic Electronic Materials: Used in the research and production of conjugated polymers and small molecules for organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and cross-coupling reactions.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and the effects of halogen substitution in heterocyclic compounds.
• Liquid Crystal and Advanced Polymer Synthesis: Intermediate for creating fluorinated monomers that impart specific dielectric and optical properties to high-performance polymers and liquid crystal displays (LCDs).

Basic Information

Product Name	2-Bromo-3-Fluorothiophene
CAS No.	32431-78-0
Molecular Formula	C4H2BrFS
Molecular Weight	181.02 g/mol
Synonyms	3-Fluoro-2-bromothiophene; 2-Bromo-3-fluorothiophene; Thiophene, 2-bromo-3-fluoro-; 3-Fluorothiophene-2-bromide; 2-Bromo-3-fluoro-thiophene; Bromofluorothiophene
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Fluorothiophene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment ensures the material meets the stringent requirements for research and commercial synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, keep containers tightly sealed when not in use. Keep away from strong acids and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.