Description

Methyl 4-Fluorothiophene-2-Carboxylate is a high-purity fluorinated heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique thiophene core and fluorine substituent enable precise molecular modifications. It is primarily utilized by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorothiophene motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in medicinal chemistry, particularly for candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or building block for developing specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs for method development, library synthesis, and exploring new chemical spaces in fluorinated heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the scale-up and production of client-specific target compounds.

Basic Information

Product Name	Methyl 4-Fluorothiophene-2-Carboxylate
CAS No.	32431-75-7
Molecular Formula	C6H5FO2S
Molecular Weight	160.16 g/mol
Synonyms	Methyl 4-fluorothiophene-2-carboxylate; 4-Fluorothiophene-2-carboxylic acid methyl ester; 2-Methoxycarbonyl-4-fluorothiophene; Methyl 4-fluoro-2-thiophenecarboxylate; 4-Fluoro-2-thiophenecarboxylic acid methyl ester; 32431-75-7; Methyl 4-fluorothiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 4-Fluorothiophene-2-Carboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality system is designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical applications, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.