Description

Thiophene, 4-Fluoro-2-Nitro- (8Ci,9Ci) is a high-value, halogenated nitro-thiophene derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both electron-withdrawing nitro and fluoro substituents on the thiophene ring, makes it indispensable for constructing complex heterocyclic systems and fine-tuning molecular properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in developing molecules with thiophene-based pharmacophores for various therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluoronitro-thiophene moiety can contribute to biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, organic semiconductors, and non-linear optical (NLO) materials due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in creating novel ligands for transition metal catalysis and organocatalysts, leveraging its ability to modulate electronic properties.
• Chemical Biology Probes: Utilized in designing fluorescent tags, enzyme inhibitors, and other molecular probes for biochemical and diagnostic research.
• Academic & Industrial R&D: A fundamental reagent for methodological studies in organic synthesis, including cross-coupling reactions and heterocyclic chemistry.

Basic Information

Product Name	Thiophene, 4-Fluoro-2-Nitro- (8Ci,9Ci)
CAS No.	32431-68-8
Molecular Formula	C4H2FNO2S
Molecular Weight	147.13 g/mol
Synonyms	4-Fluoro-2-nitrothiophene; 2-Nitro-4-fluorothiophene; 4-Fluoro-2-nitro-thiophene; 4-Fluor-2-nitrothiophen; 4-Fluoro-2-nitro-thiophene (8CI,9CI); 4-Fluoro-2-nitro-thiophene, 8CI,9CI; 2-Nitro-4-fluoro-thiophene; 4-Fluoro-2-nitrothiophene (major)
EINECS	Contact for details

Quality Control

Our Thiophene, 4-Fluoro-2-Nitro- (8Ci,9Ci) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and industrial use. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.