Description

2-Bromo-4-Fluorothiophene is a halogenated heterocyclic building block of significant importance in advanced organic synthesis. This compound matters because it serves as a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries that need it include pharmaceutical R&D for creating active pharmaceutical ingredients (APIs), agrochemical manufacturers developing novel crop protection agents, and material scientists working on specialty polymers and electronic materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the thiophene core contributes to biological activity.
• Material Science Research: Serves as a precursor for conjugated polymers and organic semiconductors used in OLEDs, solar cells, and field-effect transistors (OFETs).
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis, enabling novel cross-coupling reactions.
• Fluorine Chemistry Building Block: The presence of both bromine and fluorine atoms makes it a valuable substrate for sequential functionalization via metal-halogen exchange and nucleophilic aromatic substitution.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new heterocyclic chemistry and reaction methodologies.

Basic Information

Product Name	2-Bromo-4-Fluorothiophene
CAS No.	32431-65-5
Molecular Formula	C4H2BrFS
Molecular Weight	180.02 g/mol
Synonyms	4-Fluoro-2-bromothiophene; 2-Bromo-4-fluorothiophene; Thiophene, 2-bromo-4-fluoro-; 2-Bromo-4-fluoro-thiophene; 4-Fluoro-2-bromo-thiophene; 2-Bromo-4-fluorothiophene (principal name); 32431-65-5 (CAS); Bromofluorothiophene
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Fluorothiophene is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.