Description

3-Amino-Tetrahydro-Thiophene-3-Carboxylic Acid CAS NO 32418-99-8 is a high-value, non-proteinogenic amino acid derivative featuring a tetrahydrothiophene (thiolane) ring, making it a critical chiral building block for advanced synthesis. Its unique structure, combining a carboxylic acid and an amino group on the same carbon of a saturated sulfur heterocycle, provides versatile reactivity for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical sectors, particularly for creating novel active ingredients and sophisticated intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel active pharmaceutical ingredients (APIs), especially in protease inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the thiolane scaffold imparts specific biological activity.
• Peptidomimetics & Constrained Peptide Design: Serves as a rigid, non-natural amino acid analog to introduce conformational constraints into peptide chains, enhancing stability and bioavailability.
• Ligand & Catalyst Development: Employed in organometallic chemistry and catalysis research for constructing chelating ligands with sulfur and nitrogen donor atoms.
• Material Science Research: Investigated as a monomer or precursor for specialized polymers and functional materials with unique properties derived from the sulfur heterocycle.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.

Basic Information

Product Name	3-Amino-Tetrahydro-Thiophene-3-Carboxylic Acid
CAS No.	32418-99-8
Molecular Formula	C5H9NO2S
Molecular Weight	147.20 g/mol
Synonyms	3-Aminotetrahydrothiophene-3-carboxylic acid; 3-Amino-3-carboxytetrahydrothiophene; (3-Aminothiolan-3-yl)carboxylic acid; 3-Thiolaneacetic acid, 3-amino-; 3-Amino-3-thiolanecarboxylic acid; 3-Aminotetrahydrothiophene-3-carboxylate; 3-ATCA; 3-ATC
EINECS	Contact for details

Quality Control

Our 3-Amino-Tetrahydro-Thiophene-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.