Description

5-Fluorothiophene-2-Carbonitrile is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its value lies in the strategic combination of a reactive nitrile group and an electron-deficient thiophene ring, enabling the construction of complex molecular architectures. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and CNS-active compounds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or building block for conjugated polymers and organic electronic materials, such as OLEDs and organic semiconductors.
• Ligand and Catalyst Development: The nitrile and thiophene functionalities make it a useful precursor for creating novel ligands in coordination chemistry and catalysis.
• Fluorine Chemistry Studies: Employed in academic and industrial R&D to study the effects of fluorine substitution on the reactivity and properties of heterocyclic systems.
• Custom Synthesis: Provides a foundational structure for contract research organizations (CROs) and fine chemical manufacturers to produce bespoke compounds for client projects.

Basic Information

Product Name	5-Fluorothiophene-2-Carbonitrile
CAS No.	32415-91-1
Molecular Formula	C5H2FNS
Molecular Weight	127.14 g/mol
Synonyms	2-Cyano-5-fluorothiophene; 5-Fluoro-2-thiophenecarbonitrile; 5-Fluorothiophene-2-carbonitrile; 2-Thiophenecarbonitrile, 5-fluoro-; 5-Fluorothienyl-2-carbonitrile; 5-Fluoro-2-cyanothiophene; 5-Fluorothiophen-2-yl cyanide
EINECS	Contact for details

Quality Control

Our 5-Fluorothiophene-2-Carbonitrile is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.