Description

4-Phenylbutyldimethylchlorosilane is a versatile organosilicon reagent featuring a reactive chlorosilane group and a hydrophobic phenylbutyl chain. This compound is essential for introducing silyl protecting groups in complex organic synthesis, particularly for sensitive alcohols and polyols. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular modification and protection strategies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially where selective hydroxyl group protection is required.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides that utilize silicon-containing bioactive molecules.
• Polymer & Material Science: Serves as a surface modifying agent or a monomer precursor for creating specialized silicone polymers and hybrid organic-inorganic materials.
• Peptide & Carbohydrate Chemistry: Employed as a protecting group reagent for hydroxyl functionalities during the synthesis of complex peptides, nucleotides, and sugars.
• Chromatography Derivatization: Acts as a derivatization agent in gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) to enhance the volatility and detectability of polar analytes.
• Cross-Coupling Reactions: Can be utilized in palladium-catalyzed cross-coupling reactions (e.g., Hiyama coupling) to form carbon-carbon bonds.

Basic Information

Product Name	4-Phenylbutyldimethylchlorosilane
CAS No.	32328-67-9
Molecular Formula	C12H19ClSi
Molecular Weight	226.82 g/mol
Synonyms	Dimethyl(4-phenylbutyl)chlorosilane; (4-Phenylbutyl)dimethylchlorosilane; Chlorodimethyl(4-phenylbutyl)silane; 4-Phenylbutyldimethylsilyl chloride; Silane, chlorodimethyl(4-phenylbutyl)-; (4-Phenylbutyl)dimethylsilyl chloride
EINECS	Contact for details

Quality Control

Our 4-Phenylbutyldimethylchlorosilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, NMR, and Karl Fischer titration. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality management systems.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts with fluoride/strong alkali. Keep under an inert atmosphere (argon or nitrogen) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.