Description

Phosphoric Acid Bis[2,3-Bis[(Trimethylsilyl)Oxy]Propyl](Trimethylsilyl) Ester is a specialized organosilicon-protected phosphate derivative, serving as a critical intermediate and protecting group reagent in advanced synthetic chemistry. Its primary value lies in enabling complex multi-step syntheses by safeguarding reactive phosphate and hydroxyl functionalities under harsh reaction conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity, moisture-sensitive intermediates for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of nucleotide analogs, phospholipids, and prodrugs requiring phosphate protection.
• Agrochemical Synthesis: Used in creating advanced herbicide and insecticide molecules where phosphate ester chemistry is central to biological activity.
• Polymer & Material Science: Acts as a functional monomer or cross-linking agent for creating specialty silicones and phosphate-containing polymers with tailored properties.
• Chemical Research & Development: A versatile reagent for introducing protected phosphate groups in complex organic molecules during multi-step laboratory syntheses.
• Surface Modification Agent: Employed to modify material surfaces with silyl phosphate groups to alter wettability, adhesion, or biocompatibility.
• Ligand & Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in metal catalysis and coordination chemistry.

Basic Information

Product Name	Phosphoric Acid Bis[2,3-Bis[(Trimethylsilyl)Oxy]Propyl](Trimethylsilyl) Ester
CAS No.	32046-28-9
Molecular Formula	C21H55O8PSi5
Molecular Weight	619.16 g/mol
Synonyms	Bis(2,3-bis(trimethylsilyloxy)propyl) trimethylsilyl phosphate; Tris(trimethylsilyl) glycerol phosphate derivative; Phosphoric acid tris(trimethylsilyl) ester derivative; O,O-Bis[2,3-bis[(trimethylsilyl)oxy]propyl] O-(trimethylsilyl) phosphate; TMS-protected glycerol phosphate; Glycerol-1,2,3-tris(trimethylsilyl) phosphate; Silylated phosphate ester; CAS 32046-28-9
EINECS	Contact for details

Quality Control

Our production of Phosphoric Acid Bis[2,3-Bis[(Trimethylsilyl)Oxy]Propyl](Trimethylsilyl) Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and GC to confirm identity, purity, and the absence of critical impurities. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP and ISO 9001 compliant manufacturing for pharmaceutical and research-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition upon exposure to atmospheric moisture. Keep away from heat, open flames, and incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Gravity (20°C)	0.95 - 1.05

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.