Description

2-Thiobarbituric Acid Sodium Salt is a sodium salt derivative of thiobarbituric acid, valued for its role as a key analytical reagent and synthetic intermediate. Its primary commercial importance lies in its use as a sensitive chromogenic agent for the detection and quantification of lipid peroxidation products like malondialdehyde (MDA). This compound is essential for research and quality control laboratories in the pharmaceutical, food science, and biomedical research sectors, where precise measurement of oxidative stress is critical.

Application

• Biomarker Assay Reagent: The primary application is in the Thiobarbituric Acid Reactive Substances (TBARS) assay for measuring lipid peroxidation and oxidative stress in biological samples (e.g., serum, tissue homogenates).
• Food Quality Analysis: Used to assess the rancidity and oxidative stability of edible oils, fats, and meat products by quantifying secondary oxidation products.
• Pharmaceutical Research: Employed in drug discovery and toxicology studies to evaluate the antioxidant efficacy of compounds or the oxidative damage induced by pharmaceuticals.
• Clinical Diagnostics: Serves as a reagent in research-focused diagnostic kits for investigating conditions linked to oxidative damage, such as cardiovascular diseases and neurodegenerative disorders.
• Chemical Synthesis: Acts as a versatile building block or precursor in the synthesis of more complex heterocyclic compounds and potential pharmacologically active molecules.
• Material Science: Investigated for use in the development of sensors and indicators due to its specific colorimetric reaction with aldehydes.

Basic Information

Product Name	2-Thiobarbituric Acid Sodium Salt
CAS No.	31645-12-2
Molecular Formula	C4H3N2NaO2S
Molecular Weight	166.13 g/mol
Synonyms	Sodium 2-Thiobarbiturate; 2-Thiobarbituric Acid Sodium Salt Monohydrate; Thiobarbituric Acid Sodium Salt; TBA Sodium Salt; 4,6-Dihydroxy-2-mercaptopyrimidine Sodium Salt; Malonaldehyde Bis(dimethyl acetal) Sodium Salt (related reagent); Sodium Thiobarbiturate; NSC 401148
EINECS	Contact for details

Quality Control

Our 2-Thiobarbituric Acid Sodium Salt is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure high purity, consistent performance, and compliance with in-house specifications designed for critical research applications. A detailed Certificate of Analysis (COA) providing purity, identification, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent absorption of atmospheric moisture, which can affect purity and stability.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 2.0%
Water Content (KF)	≤ 1.5%
Heavy Metals (as Pb)	≤ 20 ppm
Solubility (in Water)	Clear, yellow solution
pH (1% Solution)	7.0 - 9.0

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.