Description

4-(2,5-Dioxo-Pyrrolidin-1-Yl)-Butyric Acid is a versatile heterocyclic carboxylic acid derivative, serving as a critical building block in advanced organic synthesis. Its bifunctional nature, featuring both a reactive N-hydroxysuccinimide (NHS) ester precursor and a carboxylic acid group, makes it invaluable for creating stable amide bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, bioconjugation, and specialty polymer industries who require high-purity intermediates for developing active pharmaceutical ingredients (APIs), diagnostic reagents, and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs requiring targeted delivery or conjugation.
• Bioconjugation Reagent: Used to functionalize proteins, peptides, antibodies, and other biomolecules by introducing a carboxylic acid handle for further coupling via NHS-ester chemistry.
• Polymer Modification: Employed to introduce functional groups into polymer backbones (e.g., PEGylation) to alter solubility, biocompatibility, or to attach targeting ligands.
• Crosslinking Agent: Facilitates the formation of stable crosslinks in hydrogel fabrication and biomaterial scaffolds for tissue engineering.
• Diagnostic Probe Synthesis: Integral for constructing fluorescent dyes, MRI contrast agents, and other diagnostic probes that require a stable linkage to biological targets.
• Surface Functionalization: Used to modify the surface of nanoparticles, chips, and other substrates with carboxyl groups for subsequent biomolecule immobilization.
• Peptide Synthesis: Serves as a protected or activated building block in solid-phase peptide synthesis (SPPS) strategies.
• Research & Development: A valuable tool compound in medicinal chemistry and chemical biology for exploring new drug candidates and biochemical pathways.

Basic Information

Product Name	4-(2,5-Dioxo-Pyrrolidin-1-Yl)-Butyric Acid
CAS No.	31601-68-0
Molecular Formula	C8H11NO4
Molecular Weight	185.18 g/mol
Synonyms	4-(2,5-Dioxopyrrolidin-1-yl)butanoic acid; 1-(3-Carboxypropyl)-2,5-pyrrolidinedione; 4-(N-Succinimidyl)butyric acid; NHS-Butyric Acid; γ-(N-Succinimidyl)butyric acid; 4-(2,5-Dioxo-1-pyrrolidinyl)butanoic acid; Butyric acid, 4-(2,5-dioxo-1-pyrrolidinyl)-; SBA (Succinimidyl Butyric Acid)
EINECS	Contact for details

Quality Control

Our 4-(2,5-Dioxo-Pyrrolidin-1-Yl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical-grade intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	95 - 100 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1 %
Single Unknown Impurity (HPLC)	≤ 0.5 %
Total Impurities (HPLC)	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.