Description

2-[2-(2-Methoxyethoxy)Ethoxy]-Ethanethiol is a specialized thiol-terminated oligo(ethylene glycol) derivative, a key building block in advanced material synthesis. Its unique structure, featuring a hydrophilic polyether chain capped with a reactive thiol group, makes it invaluable for creating functional surfaces and polymers. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and specialty polymer industries seeking to introduce specific surface chemistry or cross-linking capabilities.

Application

• Surface Functionalization & Self-Assembled Monolayers (SAMs): Used to create bio-compatible, non-fouling, or specifically reactive coatings on gold, silver, and other metal surfaces for biosensors and diagnostic devices.
• Bioconjugation & Protein Modification: Acts as a heterobifunctional linker for attaching peptides, proteins, or other biomolecules to surfaces or carrier molecules via thiol-maleimide or thiol-haloacetyl chemistry.
• Polymer Chemistry & Cross-linking Agent: Serves as a chain transfer agent (CTA) in reversible addition-fragmentation chain-transfer (RAFT) polymerization or as a cross-linker in the synthesis of hydrogels and network polymers.
• Nanoparticle Capping & Stabilization: Employed to functionalize and stabilize metallic (e.g., gold, quantum dots) or polymeric nanoparticles, imparting water solubility and providing a handle for further conjugation.
• Lubricant & Fuel Additive Intermediate: Used in the synthesis of multifunctional additives where the thiol group provides metal-binding or anti-wear properties, and the polyether chain offers solubility.
• Adhesive & Sealant Formulations: Incorporated as a reactive modifier in epoxy, polyurethane, or silicone systems to enhance adhesion, flexibility, or curing characteristics.

Basic Information

Item	Details
Product Name	2-[2-(2-Methoxyethoxy)Ethoxy]-Ethanethiol
CAS No.	31521-83-2
Molecular Formula	C7H16O3S
Molecular Weight	180.26 g/mol
Synonyms	2-(2-(2-Methoxyethoxy)ethoxy)ethanethiol; 2-[2-(2-Methoxyethoxy)ethoxy]ethanethiol; 1-Methoxy-2-[2-(2-sulfanylethoxy)ethoxy]ethane; Triethylene glycol monomethyl ether thiol; mPEG3-thiol; PEG3 methyl ether thiol; 8-Mercapto-3,6-dioxaoctyl methyl ether; Thiol-PEG3-OMe
EINECS	Contact for details

Quality Control

Our 2-[2-(2-Methoxyethoxy)Ethoxy]-Ethanethiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopic methods, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its thiol functionality, it is easily oxidized; minimize headspace and exposure to air after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.