Description

1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide is a versatile organic building block and key synthetic intermediate characterized by its fused isoquinoline ring system and sulfonamide functional group. This compound matters for its role as a crucial precursor in the development of complex pharmacologically active molecules, particularly within medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of new drug candidates, especially those targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of bioactive molecules, including potential drug candidates for neurological and psychiatric conditions.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the development of novel therapeutic agents.
• Organic Synthesis Building Block: Utilized in the construction of complex heterocyclic compounds due to its reactive sulfonamide and tetrahydroisoquinoline moieties.
• Chemical Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical R&D and manufacturing.
• Biochemical Research: May be employed in the study of enzyme inhibition or as a ligand in biochemical assays.

Basic Information

Product Name	1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide
CAS No.	31404-61-2
Molecular Formula	C9H12N2O2S
Molecular Weight	212.27 g/mol
Synonyms	7-Sulfamoyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-isoquinolinesulfonamide; THIQ-7-Sulfonamide; 1,2,3,4-Tetrahydroisoquinoline-7-sulfonic acid amide; 7-Aminosulfonyl-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-7-sulfamoylisoquinoline; Isoquinoline-7-sulfonamide, 1,2,3,4-tetrahydro-
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydroisoquinoline-7-Sulfonamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and residual solvents are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.