Description

(1R,5R,6R)-4-[(E)-3-Hydroxy-3-Methyl-1-Butenyl]-5β-Hydroxy-7-Oxabicyclo[4.1.0]Hepta-3-Ene-2-One is a high-purity, advanced pharmaceutical intermediate characterized by its complex bicyclic structure with multiple chiral centers. This compound is critical for the synthesis of prostaglandin analogs and other bioactive molecules, offering a key building block for precise and efficient chemical transformations. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis sectors requiring high stereochemical purity and reliable supply chains.

Application

• Key Intermediate in Prostaglandin Synthesis: Serves as a crucial precursor in the production of prostaglandin E and F series analogs for pharmaceutical applications.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and development of new therapeutic agents targeting inflammation, pain, and cardiovascular conditions.
• Asymmetric Synthesis: Employed as a chiral synthon in complex, stereoselective organic synthesis due to its defined (1R,5R,6R) configuration.
• Fine Chemical Manufacturing: Integral in the multi-step synthesis of high-value, complex organic molecules for clinical and commercial use.
• Biochemical Research: Used as a tool compound to study enzyme pathways and receptor interactions related to prostanoid biology.

Basic Information

Product Name	(1R,5R,6R)-4-[(E)-3-Hydroxy-3-Methyl-1-Butenyl]-5β-Hydroxy-7-Oxabicyclo[4.1.0]Hepta-3-Ene-2-One
CAS No.	31298-57-4
Molecular Formula	C12H16O4
Molecular Weight	224.25 g/mol
Synonyms	4-[(1E)-3-Hydroxy-3-methyl-1-buten-1-yl]-5β-hydroxy-7-oxabicyclo[4.1.0]hept-3-en-2-one; (1R,5R,6R)-4-[(E)-3-Hydroxy-3-methylbut-1-enyl]-5β-hydroxy-7-oxabicyclo[4.1.0]hept-3-en-2-one; Prostaglandin Intermediate; 7-Oxabicyclo[4.1.0]hept-3-en-2-one derivative; (E)-Isomer of the hydroxy-methylbutenyl oxabicycloheptenone; PGE1 Synthetic Intermediate; Corey Lactone Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high stereochemical purity. Quality is verified through comprehensive analytical methods including HPLC, chiral chromatography, and NMR to confirm identity, purity, and isomeric composition. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical parameters. We support development and commercial projects requiring compliance with cGMP and other relevant regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1R,5R,6R isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.