Description

Ethyl 2-Amino-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its thiazole core and trifluoromethyl group. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific bioisosteric properties. It is primarily needed by research institutions and pharmaceutical manufacturers developing next-generation agrochemicals and medicinal compounds, where its unique structure enables precise molecular modifications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Research: Serves as a precursor in developing advanced pesticides and herbicides, leveraging the bioactivity of the thiazole moiety.
• Chemical Synthesis: Used in organic chemistry research for constructing complex heterocyclic frameworks and introducing the trifluoromethyl group into target molecules.
• Material Science: Potential application in the development of specialty chemicals and functional materials with specific electronic or surface properties.

Basic Information

Product Name	Ethyl 2-Amino-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate Hydrochloride
CAS No.	31119-10-5
Molecular Formula	C7H8F3N3O2S • HCl
Molecular Weight	291.67 g/mol (Free base: 255.21 g/mol)
Synonyms	2-Amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid ethyl ester hydrochloride; Ethyl 2-amino-4-(trifluoromethyl)thiazole-5-carboxylate hydrochloride; 5-Carbethoxy-2-amino-4-trifluoromethylthiazole hydrochloride; ATCT hydrochloride; 5-Ethoxycarbonyl-2-amino-4-trifluoromethylthiazole HCl; 31119-10-5; Ethyl α-amino-β-(trifluoromethyl)thiazole-4-carboxylate hydrochloride (alternative)
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-4-(Trifluoromethyl)-1,3-Thiazole-5-Carboxylate Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) documenting purity, related substances, and other critical parameters are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.