Description

6-Amino-1-Hexanethiol, Hydrochloride is a bifunctional organic compound featuring both a primary amine and a thiol group, stabilized as a hydrochloride salt. This dual functionality makes it a valuable building block for the synthesis of heterobifunctional crosslinkers and surface modifiers in advanced materials science. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nanotechnology sectors who require precise molecular conjugation and controlled surface functionalization.

Application

• Bioconjugation & Crosslinking: A key reagent for creating heterobifunctional crosslinkers (e.g., SMCC derivatives) used in antibody-drug conjugate (ADC) development and protein-protein conjugation.
• Surface Modification & Self-Assembled Monolayers (SAMs): Used to functionalize gold, silver, and other metal surfaces via the thiol group, with the amine group providing a handle for further chemical attachment.
• Polymer & Dendrimer Synthesis: Serves as a monomer or branching unit in the creation of functional polymers, dendrimers, and hydrogels with tailored properties.
• Peptide & Oligonucleotide Synthesis: Acts as a protected or deprotected intermediate for introducing thiol or amine handles into synthetic peptides and oligonucleotides.
• Nanoparticle Functionalization: Critical for coating quantum dots, gold nanoparticles, and other nanomaterials to impart stability and bio-compatibility for diagnostic and therapeutic applications.
• Sensor Development: Employed in the fabrication of electrochemical and optical biosensors by creating specific receptor layers on transducer surfaces.
• Chromatography & Affinity Media: Used as a ligand precursor for immobilizing proteins or other biomolecules onto solid supports for chromatography and purification.

Basic Information

Product Name	6-Amino-1-Hexanethiol, Hydrochloride
CAS No.	31098-40-5
Molecular Formula	C6H15NS • HCl
Molecular Weight	169.71 g/mol
Synonyms	6-Aminohexane-1-thiol Hydrochloride; 6-Mercaptohexylamine Hydrochloride; 1-Hexanethiol, 6-amino-, hydrochloride; 6-Aminohexyl Mercaptan Hydrochloride; Aminohexanethiol Hydrochloride; (6-Mercaptohexyl)ammonium Chloride; NSC 334365; 6-AHT • HCl
EINECS	Contact for details

Quality Control

Our 6-Amino-1-Hexanethiol, Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and easily oxidized nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.