Description

2-Acetyl-5-Iodothiophene is a high-purity, functionalized heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in providing a versatile molecular scaffold for constructing complex molecules, particularly in pharmaceutical and materials science research. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the thiophene moiety for bioactivity.
• Material Science: Serves as a building block for organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to its electron-rich thiophene core.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl systems.
• Chemical Biology: Used as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Item	Detail
Product Name	2-Acetyl-5-Iodothiophene
CAS No.	30955-94-3
Molecular Formula	C6H5IOS
Molecular Weight	252.07 g/mol
Synonyms	1-(5-Iodothiophen-2-yl)ethanone; 5-Iodo-2-acetylthiophene; 2-Acetyl-5-iodothiophene; 2-Acetyl-5-iodo-thiophene; 5-Iodo-2-thienyl methyl ketone; 1-(5-Iodo-2-thienyl)ethanone; Ethanone, 1-(5-iodo-2-thienyl)-
EINECS	Contact for details

Quality Control

Our 2-Acetyl-5-Iodothiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material is suitable for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.