Description

L-4-Hydroxyphenyl-3,5-D2-Alanine is a deuterium-labeled isotopologue of the amino acid L-tyrosine, specifically deuterated at the 3 and 5 positions of the phenyl ring. This compound is a critical tool in pharmaceutical research and development, enabling advanced metabolic and pharmacokinetic studies through mass spectrometry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for use as an internal standard, a tracer in drug metabolism studies, and in the synthesis of labeled peptides and proteins.

Application

• Internal Standard for LC-MS/MS: Provides high accuracy and precision in the quantitative bioanalysis of L-tyrosine and related compounds in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a stable isotope tracer to study the absorption, distribution, metabolism, and excretion (ADME) profiles of tyrosine-based drugs.
• Proteomics and Metabolic Research: Used in quantitative proteomics and metabolic flux analysis to investigate protein turnover and pathway dynamics.
• Synthesis of Labeled Biomolecules: Acts as a building block for the synthesis of deuterium-labeled peptides, proteins, and other bioactive molecules.
• Diagnostic Agent Development: Employed in the research and development of novel diagnostic agents and imaging probes.
• Quality Control Reference: Functions as a certified reference material (CRM) in analytical laboratories for method validation and quality assurance.

Basic Information

Product Name	L-4-Hydroxyphenyl-3,5-D2-Alanine
CAS No.	30811-19-9
Molecular Formula	C9H9D2NO3
Molecular Weight	183.20 g/mol
Synonyms	L-Tyrosine-3,5-d2; (2S)-2-Amino-3-(4-hydroxy-3,5-dideuteriophenyl)propanoic acid; Deuterated L-Tyrosine; L-Tyrosine-d2; 3,5-Dideutero-L-tyrosine; L-Tyr-d2; (S)-Tyrosine-3,5-d2; 4-Hydroxy-DL-phenylalanine-3,5-d2 (racemic mixture)
EINECS	Contact for details

Quality Control

Our L-4-Hydroxyphenyl-3,5-D2-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure high chemical and isotopic purity, meeting the stringent requirements for research and development. Certificates of Analysis (COA) detailing purity, isotopic enrichment, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (NMR)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.