Description

D-Glucose-2-D1 is a stable isotope-labeled analog of D-glucose, specifically deuterated at the C-2 position. This precise labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing a non-radioactive tracer for studying glucose pathways. It is primarily utilized by research institutions, pharmaceutical developers, and analytical laboratories engaged in metabolomics, drug metabolism studies (DMPK), and the production of internal standards for mass spectrometry.

Application

• Metabolic Pathway Tracing: Used as a stable, non-radioactive tracer in in vitro and in vivo studies to elucidate glycolysis, gluconeogenesis, and the pentose phosphate pathway.
• Mass Spectrometry Internal Standard: Serves as a critical internal standard for the accurate quantification of endogenous D-glucose in biological matrices (e.g., plasma, serum, cell lysates) via LC-MS/MS or GC-MS.
• Drug Metabolism & Pharmacokinetics (DMPK): Employed in pharmaceutical research to track the metabolic fate of glucose analogs or to study drug-induced alterations in carbohydrate metabolism.
• NMR Spectroscopy: Acts as a probe in nuclear magnetic resonance (NMR) studies to investigate enzyme mechanisms and metabolic flux analysis (MFA).
• Diagnostic Reagent Manufacturing: Used in the formulation and calibration of advanced diagnostic assays and kits for metabolic disorders like diabetes.
• Biochemical Research: Essential for studying isotope effects on enzyme kinetics and for validating new analytical methodologies in biochemistry.

Basic Information

Product Name	D-Glucose-2-D1
CAS No.	30737-83-8
Molecular Formula	C6H11DO6
Molecular Weight	181.16 g/mol (for monoisotopic mass)
Synonyms	2-Deuterio-D-glucose; D-(+)-Glucose-2-d; Deuterated D-glucose (C-2); 2-Deutero-D-glucopyranose; D-Glucose-2-d1; [2-2H]Glucose; (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal-2-d; Stable Isotope Labeled D-Glucose.
EINECS	Contact for details

Quality Control

Our D-Glucose-2-D1 is produced and handled under strict quality protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (atom % D), chemical purity, and specific optical rotation. We ensure compliance with relevant standards for high-purity biochemical reagents. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (Chemical Purity)
Isotopic Enrichment	≥ 98.0 atom % D (at C-2)
Specific Optical Rotation	+52.5° to +53.5° (c=10, H2O)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.