Description

Ethyl 3-Hydroxy-3-Methyl-D3-Butyrate--D3 is a high-purity, deuterium-labeled derivative of ethyl 3-hydroxy-3-methylbutyrate, a key intermediate in organic synthesis. This compound is specifically valued for its role as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries who require precise metabolic studies, pharmacokinetic profiling, and high-fidelity quality control.

Application

• As a stable isotope-labeled internal standard (SIL-IS) for the accurate quantification of HMB and related metabolites in biological matrices via LC-MS/MS and GC-MS.
• Critical intermediate in the synthesis of deuterium-labeled pharmaceutical compounds for drug metabolism and pharmacokinetics (DMPK) studies.
• Used in metabolomics and proteomics research to trace biochemical pathways and improve data reliability.
• Key reagent for developing certified reference materials (CRMs) and analytical standards for regulatory compliance and quality assurance.
• Employed in nutritional and sports science research to precisely monitor HMB levels and their physiological effects.
• Facilitates impurity profiling and degradation studies in pharmaceutical development by serving as a tracer.

Basic Information

Product Name	Ethyl 3-Hydroxy-3-Methyl-D3-Butyrate--D3
CAS No.	30385-86-5
Molecular Formula	C7H11D3O3
Molecular Weight	149.21 g/mol (for deuterated form)
Synonyms	Ethyl 3-Hydroxy-3-methylbutyrate-d3; Ethyl HMB-d3; 3-Hydroxy-3-methylbutyric acid ethyl ester-d3; Deuterated Ethyl β-Hydroxy β-methylbutyrate; (D3)-Ethyl 3-hydroxy-3-methylbutanoate; Ethyl 3-hydroxy-3-methyl[2,2,2-2H3]butyrate; 30385-86-5; HMB ethyl ester-d3
EINECS	Contact for details

Quality Control

Every batch of Ethyl 3-Hydroxy-3-Methyl-D3-Butyrate--D3 is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive analysis via NMR, MS, and HPLC to confirm identity, assay, and deuterium enrichment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This material is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.