Description

Bis(Trimethylsilyloxy)-Phosphine CAS NO 30148-50-6 is a specialized organosilicon-phosphorus reagent featuring a reactive P-H bond protected by bulky trimethylsilyloxy groups. This compound matters as a versatile synthon for introducing phosphine oxide or phosphonate functionalities under mild conditions, offering superior stability and handling compared to more sensitive phosphorus precursors. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel phosphonate-based prodrugs and bioactive molecules targeting various disease pathways.
• Agrochemical Synthesis: Used in creating advanced herbicide and pesticide intermediates, leveraging its phosphorus moiety for enhanced biological activity.
• Ligand Precursor: Serves as a starting material for the preparation of sophisticated phosphine ligands used in homogeneous catalysis, including cross-coupling reactions.
• Flame Retardant Additive Development: Investigated as a reactive component in the development of new-generation, silicon-phosphorus based flame retardants for polymers.
• Material Science Research: Employed in surface modification and the synthesis of hybrid inorganic-organic materials (HIOMs) with tailored properties.
• Process Chemistry: Valued for its stability, enabling safer scale-up and more efficient manufacturing processes for phosphorus-containing target compounds.

Basic Information

Product Name	Bis(Trimethylsilyloxy)-Phosphine
CAS No.	30148-50-6
Molecular Formula	C6H21O2PSi2
Molecular Weight	224.38 g/mol
Synonyms	Phosphinous Acid, Bis(trimethylsilyl) Ester; Bis(trimethylsiloxy)phosphine; Hexamethyldisiloxane, Phosphinous Acid Derivative; (Trimethylsiloxy)phosphine Dimer; O,O-Bis(trimethylsilyl) Phosphonite; Phosphonous Acid Bis(trimethylsilyl) Ester; P-Hydroxy-bis(trimethylsiloxy)phosphine; TMS-Protected Phosphinous Acid
EINECS	Contact for details

Quality Control

Our Bis(Trimethylsilyloxy)-Phosphine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR (1H, 13C, 31P) and chromatographic methods (GC/HPLC), to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 95.0%
31P NMR Purity	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.