Description

L-Aspartic-2,3,3-D3 Acid is a stable isotope-labeled derivative of the essential amino acid L-aspartic acid, specifically deuterated at the 2,3,3 positions. This high-purity compound is critical for advanced research and analytical applications where precise molecular tracking and quantification are required. It is primarily utilized by scientists and manufacturers in the pharmaceutical, metabolic research, and analytical chemistry sectors for use as an internal standard in mass spectrometry and NMR spectroscopy.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for the accurate quantification of L-aspartic acid and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Metabolic Pathway Tracing: Used in stable isotope-resolved metabolomics (SIRM) studies to elucidate the dynamics of the urea cycle, amino acid metabolism, and neurotransmitter synthesis.
• Pharmaceutical Research & Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies for drug candidates targeting amino acid pathways.
• NMR Spectroscopy: Serves as a valuable probe in nuclear magnetic resonance studies due to the distinct signal of deuterium, aiding in structural and dynamic analysis of biomolecules.
• Biochemical Assay Development: Used to calibrate and validate enzymatic assays and diagnostic kits that measure aspartate levels.
• Nutritional Science Research: Applied in studies investigating protein metabolism, amino acid requirements, and isotopic labeling in nutritional products.

Basic Information

Product Name	L-Aspartic-2,3,3-D3 Acid
CAS No.	3842-25-9
Molecular Formula	C4H4D3NO4
Molecular Weight	136.12 g/mol
Synonyms	(2S)-2-Aminobutanedioic-2,3,3-d3 Acid; L-Aspartic Acid-2,3,3-d3; (S)-Aminosuccinic-2,3,3-d3 Acid; Aspartic Acid-d3 (2,3,3); Deuterated L-Aspartic Acid; L-Asp-d3; 2,3,3-D3-L-Aspartic Acid; (S)-2-Amino-1,4-dicarboxybutane-2,3,3-d3
EINECS	223-348-4

Quality Control

Our L-Aspartic-2,3,3-D3 Acid is manufactured under strict quality systems to ensure the high isotopic and chemical purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D%), chemical purity, and specific analytical results. We adhere to relevant industry standards for fine chemicals and can provide material suitable for research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97.0%
Optical Rotation	[α]20/D: +24.5° to +26.0° (c=1 in 5M HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.