Description

(-)-[(S)-1-Bromoethyl]Benzene is a high-purity, chiral organobromine compound of significant synthetic utility. This enantiomerically pure building block is essential for introducing the (S)-1-phenylethyl moiety into complex molecular architectures, enabling the stereoselective synthesis of pharmaceuticals and advanced materials. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require precise stereochemical control in their synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the asymmetric synthesis of active pharmaceutical ingredients (APIs), particularly in the development of CNS agents, anti-inflammatory drugs, and other therapeutics.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where the specific stereochemistry is crucial for biological activity and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral phosphine and nitrogen-donor ligands used in asymmetric catalysis (e.g., hydrogenation, cross-coupling reactions).
• Material Science Research: Employed in the synthesis of chiral liquid crystals, polymers, and other functional materials with specific optical or electronic properties.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution (SN2) and cross-coupling reactions (e.g., Suzuki, Negishi) to construct complex, enantiomerically enriched molecules.

Basic Information

Item	Detail
Product Name	(-)-[(S)-1-Bromoethyl]Benzene
CAS No.	3756-40-9
Molecular Formula	C8H9Br
Molecular Weight	185.06 g/mol
Synonyms	(S)-(-)-1-Bromo-1-phenylethane; (S)-1-Bromoethylbenzene; (S)-α-Methylbenzyl bromide; (S)-(-)-α-Bromoethylbenzene; (S)-Phenethyl bromide; (S)-1-Phenylethyl bromide; (S)-sec-Phenethyl bromide; (S)-Bromo(1-phenylethyl)
EINECS	223-158-7

Quality Control

Our (-)-[(S)-1-Bromoethyl]Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated area. Recommended storage temperature is 2-8°C to maintain stability and minimize volatility. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.