Description

p-Tolyltrimethylsilane is a versatile organosilicon compound that serves as a key building block and protective reagent in advanced organic synthesis. Its value lies in its ability to introduce the robust and stable p-tolyltrimethylsilyl group, which can act as a protective moiety for alcohols and phenols or as a functional handle in cross-coupling reactions. This chemical is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials industries who require high-purity intermediates for complex molecule construction.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) where the silyl group provides temporary protection for sensitive functional groups during multi-step sequences.
• Agrochemical Synthesis: Serves as a precursor or reagent in the development of novel pesticides and herbicides, leveraging its stability and reactivity.
• Material Science Research: Employed in the creation of advanced organic materials, including liquid crystals and polymers, where the introduction of silylated aromatic groups modifies physical properties.
• Cross-Coupling Reactions: Acts as an organometallic reagent in palladium-catalyzed cross-coupling reactions, such as the Hiyama coupling, to form new carbon-carbon bonds.
• Organic Synthesis Reagent: Functions as a versatile reagent for the silylation of various nucleophiles, providing a stable protecting group that is easily removable under mild conditions.
• Laboratory Research & Development: A valuable tool for medicinal chemistry and process chemistry groups exploring new synthetic routes and methodologies.

Basic Information

Product Name	p-Tolyltrimethylsilane
CAS No.	3728-43-6
Molecular Formula	C10H16Si
Molecular Weight	164.32 g/mol
Synonyms	(4-Methylphenyl)trimethylsilane; 4-Methylphenyltrimethylsilane; 1-Trimethylsilyl-4-methylbenzene; p-Tolyl-trimethyl-silane; Trimethyl(p-tolyl)silane; Trimethyl(4-methylphenyl)silane; Silane, trimethyl(4-methylphenyl)-; Toluene, 4-(trimethylsilyl)-
EINECS	223-074-5

Quality Control

Our p-Tolyltrimethylsilane is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, NMR, and Karl Fischer titration to confirm identity, potency, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.