Description

1H-Benzimidazole, 5-Fluoro-2-(Trifluoromethyl)- CAS NO 3671-47-4 is a high-value fluorinated benzimidazole derivative, a crucial heterocyclic building block in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which combines fluorine and trifluoromethyl groups to impart significant electronic and steric properties, enabling the development of novel compounds with enhanced bioactivity and material characteristics. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, serving as a key intermediate for creating active pharmaceutical ingredients (APIs), crop protection agents, and specialty polymers.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for antiviral, anticancer, and anti-inflammatory therapies, leveraging its benzimidazole core for targeted biological activity.
• Agrochemical Synthesis: Used in the development of next-generation fungicides, herbicides, and insecticides, where the fluorine and trifluoromethyl groups enhance metabolic stability and binding affinity.
• Material Science Research: Serves as a building block for advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport materials, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create specialized ligands for catalysis, useful in facilitating challenging cross-coupling and fluorination reactions.
• Chemical Biology Probe: Utilized in medicinal chemistry to develop molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1H-Benzimidazole, 5-Fluoro-2-(Trifluoromethyl)-
CAS No.	3671-47-4
Molecular Formula	C8H4F4N2
Molecular Weight	204.13 g/mol
Synonyms	5-Fluoro-2-(trifluoromethyl)-1H-benzimidazole; 5-Fluoro-2-(trifluoromethyl)benzimidazole; 2-(Trifluoromethyl)-5-fluorobenzimidazole; 5-Fluoro-2-trifluoromethyl-1H-benzimidazole; Benzimidazole, 5-fluoro-2-(trifluoromethyl)-; 3671-47-4; 5-Fluoro-2-trifluoromethylbenzimidazole; FTBZ
EINECS	Contact for details

Quality Control

Our 1H-Benzimidazole, 5-Fluoro-2-(Trifluoromethyl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.