Description

6-Chloro-4-Nitro-2-(Trifluoromethyl)-1H-Benzimidazole is a high-value, multi-functional heterocyclic building block characterized by its unique trifluoromethyl and nitro substituents. This compound is essential for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel benzimidazole-based drugs, including potential antivirals, antifungals, and kinase inhibitors.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, where the trifluoromethyl group often improves lipophilicity and bioactivity.
• Material Science: Serves as a building block for advanced organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Dye & Pigment Synthesis: Employed in the creation of specialized dyes and pigments due to the strong electron-withdrawing nature of its substituents.
• Biochemical Probe Development: Utilized in medicinal chemistry to create molecular probes for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	6-Chloro-4-Nitro-2-(Trifluoromethyl)-1H-Benzimidazole
CAS No.	3671-18-9
Molecular Formula	C8H3ClF3N3O2
Molecular Weight	265.57 g/mol
Synonyms	2-(Trifluoromethyl)-6-chloro-4-nitro-1H-benzimidazole; 6-Chloro-4-nitro-2-trifluoromethylbenzimidazole; 1H-Benzimidazole, 6-chloro-4-nitro-2-(trifluoromethyl)-; 3671-18-9; 6-Chloro-4-nitro-2-(trifluoromethyl)benzimidazole; 2-Trifluoromethyl-6-chloro-4-nitrobenzimidazole
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-4-Nitro-2-(Trifluoromethyl)-1H-Benzimidazole is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.