Description

n-Methyl-D3-Acetamide is a deuterium-labeled isotopologue of N-methylacetamide, serving as a critical internal standard and tracer in advanced analytical and synthetic chemistry. Its value lies in providing unmatched precision for quantitative analysis and metabolic studies, eliminating interference from endogenous compounds. This high-purity material is essential for researchers and quality control laboratories in the pharmaceutical, agrochemical, and analytical instrument manufacturing industries.

Application

• Quantitative NMR (qNMR) Internal Standard: Used as a precise, non-interfering reference standard for the quantification of organic compounds and impurities in complex matrices.
• Mass Spectrometry (MS) & LC-MS: Acts as a stable isotope-labeled internal standard (SIL-IS) for accurate mass spectrometry-based quantification in pharmacokinetic and metabolomic studies.
• Metabolic Pathway Tracing: Employed in deuterium labeling studies to investigate drug metabolism, biochemical pathways, and reaction mechanisms.
• Pharmaceutical R&D: Critical for developing and validating analytical methods for Active Pharmaceutical Ingredients (APIs) under Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) guidelines.
• Chemical Synthesis Research: Utilized as a building block or mechanistic probe in the synthesis of novel deuterated compounds for material science and electronics.
• Quality Control & Reference Standards: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring data integrity in regulatory submissions.

Basic Information

Product Name	n-Methyl-D3-Acetamide
CAS No.	3669-71-4
Molecular Formula	C3D3H4NO
Molecular Weight	76.11 g/mol
Synonyms	N-Methylacetamide-d3; N-Methyl-D3-acetamide; Acetamide-d3, N-methyl-; Deuterated N-methylacetamide; (Trideuteriomethyl)(acetyl)amine; N-Methylacetamide (methyl-d3); CD3NHC(O)CH3
EINECS	Contact for details

Quality Control

Our n-Methyl-D3-Acetamide is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for research and analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D-atom %), chemical purity, and solvent residues. We adhere to industry best practices, and specifications can be tailored to meet the rigorous demands of GLP/GMP environments and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage under inert atmosphere, please contact our technical team.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (NMR/MS)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.