Description

p-Cresol-2,3,5,6-D4,Od is a deuterium-labeled isotopologue of p-cresol, a key phenolic compound. This high-purity labeled standard is critical for ensuring analytical accuracy and traceability in quantitative mass spectrometry and NMR studies. It is primarily required by researchers and quality control laboratories in the pharmaceutical, environmental, and metabolomics fields for use as an internal standard, tracer, or reference material.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for the precise quantification of p-cresol and related metabolites in complex biological matrices (e.g., plasma, urine) via GC-MS or LC-MS.
• Metabolic Pathway Tracing: Used in biomedical and microbiological research to elucidate the degradation pathways and metabolic fate of phenolic compounds.
• NMR Spectroscopy Studies: Serves as a valuable tool for structural elucidation and mechanistic studies due to the distinct spectroscopic signature of deuterium atoms.
• Environmental Analysis: Enables accurate monitoring and quantification of cresol isomers as environmental pollutants in water and soil samples.
• Pharmaceutical Impurity Profiling: Supports method development and validation for the detection and quantification of process-related impurities or degradants in drug substances.
• Quality Control Reference Material: Provides a certified reference for calibrating analytical instruments and validating testing methods in compliance with GLP/GMP guidelines.

Basic Information

Product Name	p-Cresol-2,3,5,6-D4,Od
CAS No.	3646-98-8
Molecular Formula	C7D4H4O
Molecular Weight	112.15 g/mol
Synonyms	4-Methylphenol-2,3,5,6-d4; p-Cresol-d4; 4-Hydroxytoluene-d4; 1-Hydroxy-4-methylbenzene-d4; 1-Methyl-4-hydroxybenzene-d4; Deuterated p-cresol; [2,3,5,6-2H4]-4-Methylphenol; 4-Methyl[2,3,5,6-2H4]phenol
EINECS	Contact for details

Quality Control

Every batch of p-Cresol-2,3,5,6-D4,Od is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing isotopic purity (atom % D), chemical purity (by HPLC/GC), and identity confirmation (by NMR/MS). Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 98.0% (chemical purity)
Isotopic Purity (Atom % D)	≥ 98.0% (by MS)
Isotopic Enrichment	≥ 99% at labeled positions
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.