Description

Diethyl (2-Oxo-2-Phenylethyl)Phosphonate is a high-value organophosphorus compound, specifically a phosphonate ester, widely recognized for its role as a key synthetic intermediate. Its primary commercial importance lies in its utility as a Horner-Wadsworth-Emmons (HWE) reagent, enabling the efficient synthesis of α,β-unsaturated carbonyl compounds. This product is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing α,β-unsaturated ketone or ester moieties.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators that require specific olefination steps.
• Fine Chemical Manufacturing: Serves as a versatile building block for creating complex fragrance molecules, dyes, and specialty polymers.
• Academic & Industrial R&D: A staple reagent in organic synthesis laboratories for method development and the construction of complex molecular architectures.
• Material Science Precursor: Potential use in the synthesis of functionalized ligands for catalysis or novel phosphorus-containing materials.

Basic Information

Product Name	Diethyl (2-Oxo-2-Phenylethyl)Phosphonate
CAS No.	3453-00-7
Molecular Formula	C12H17O4P
Molecular Weight	256.23 g/mol
Synonyms	Diethyl (oxo(phenyl)methyl)phosphonate; (2-Oxo-2-phenylethyl)phosphonic acid diethyl ester; Diethyl (α-oxobenzyl)phosphonate; Benzoyl methylene phosphonate diethyl ester; Diethyl benzoylmethylphosphonate; HWE Reagent (for benzaldehyde); Phosphonoacetic acid, benzoyl-, diethyl ester; EINECS 222-376-7
EINECS	222-376-7

Quality Control

Our production of Diethyl (2-Oxo-2-Phenylethyl)Phosphonate adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including HPLC, GC, and NMR to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP-compliant applications where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.