Description

1,3-Bis(Trimethylsilyl)Uracil is a key organosilicon-protected derivative of the nucleobase uracil, widely used as a versatile building block in organic synthesis. Its primary value lies in its ability to act as a silylating agent and a protected intermediate, facilitating complex reactions with high selectivity and yield. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of nucleoside analogs, modified oligonucleotides, and other fine chemicals.

Application

• Pharmaceutical Intermediate: A critical protected precursor in the synthesis of antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used as a silylated monomer for the preparation of modified RNA and DNA strands in medicinal chemistry and diagnostics.
• Agrochemical Research: Serves as a building block for creating novel pesticides and herbicides with specific biological activity.
• Chemical Synthesis: Functions as a versatile silylating agent to introduce the trimethylsilyl (TMS) group, protecting reactive sites during multi-step syntheses.
• Material Science: Employed in the development of specialty polymers and advanced organic electronic materials.
• Academic & R&D: A valuable reagent for methodological development and exploring new reaction pathways in university and industrial laboratories.

Basic Information

Item	Details
Product Name	1,3-Bis(Trimethylsilyl)Uracil
CAS No.	3442-82-8
Molecular Formula	C10H20N2O2Si2
Molecular Weight	244.45 g/mol
Synonyms	1,3-Bis(trimethylsilyl)uracil; Uracil, 1,3-bis(trimethylsilyl)-; 1,3-Bis-O-(trimethylsilyl)uracil; 1,3-Di-O-trimethylsilyluracil; N,O-Bis(trimethylsilyl)uracil; 1,3-BTMS-uracil; Uracil, bis(trimethylsilyl) derivative; 3442-82-8 (CAS)
EINECS	222-357-5

Quality Control

Every batch of 1,3-Bis(Trimethylsilyl)Uracil is produced and tested under strict quality management protocols to ensure consistency and purity for demanding synthetic applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.