Description

(-)-Coclaurine Hydrochloride is a high-purity, enantiomerically pure isoquinoline alkaloid derivative. This compound serves as a critical chiral building block and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutics, particularly within the fields of neuroscience and cardiovascular research.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex alkaloids and potential active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies targeting adrenergic and serotonergic receptors.
• Asymmetric Synthesis: Employed as a chiral pool reagent or ligand in stereoselective chemical transformations.
• Neuroscience Research: Investigated for its biological activity and as a model compound in studying neurotransmitter pathways.
• Quality Control & Analytical Testing: Serves as a high-purity certified reference material (CRM) for HPLC, LC-MS, and NMR method development and validation.

Basic Information

Product Name	(-)-Coclaurine Hydrochloride
CAS No.	3422-42-2
Molecular Formula	C17H19NO3·HCl
Molecular Weight	321.80 g/mol
Synonyms	(-)-Coclaurine HCl; (1R)-1-[(4-Hydroxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride; Norcoclaurine hydrochloride (enantiomer); Higenamine precursor; 6,7-Dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; (R)-Coclaurine hydrochloride
EINECS	Contact for details

Quality Control

Our (-)-Coclaurine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and development applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.