Description

(6,7-3H2)Estra-1,3,5(10)-Triene-3,17β-Diol CAS NO 3416-23-7 is a deuterium-labeled analog of the endogenous hormone estradiol, specifically labeled at the 6 and 7 positions. This compound is a critical tool for researchers requiring high specificity and sensitivity in analytical and metabolic studies. It is primarily utilized in pharmaceutical R&D, clinical diagnostics, and academic research for applications such as internal standards in mass spectrometry and tracer studies in endocrinology.

Application

• Internal Standard for LC-MS/MS: Provides precise quantification of endogenous estradiol in complex biological matrices like serum, plasma, and tissue homogenates.
• Metabolic Pathway Tracing: Used in pharmacokinetic and drug metabolism studies to track the distribution and biotransformation of estrogenic compounds.
• Biomarker Assay Development: Essential for the validation and calibration of high-sensitivity diagnostic assays for hormonal disorders.
• Endocrine Disruptor Research: Serves as a reference compound in studies investigating the impact of environmental chemicals on the endocrine system.
• Pharmaceutical Quality Control: Employed in the analysis and stability testing of estrogen-based pharmaceutical formulations.

Basic Information

Product Name	(6,7-3H2)Estra-1,3,5(10)-Triene-3,17β-Diol
CAS No.	3416-23-7
Molecular Formula	C18H22D2O2
Molecular Weight	274.40 g/mol
Synonyms	[2,4-2H2]Estradiol; [6,7-2H2]-17β-Estradiol; 6,7-Dideutero-17β-estradiol; Deuterated Estradiol; d2-Estradiol; 3,17β-Dihydroxy-6,7-dideutero-estra-1,3,5(10)-triene; Estradiol-6,7-d2
EINECS	Contact for details

Quality Control

Every batch of our deuterated estradiol is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR and mass spectrometry to confirm the position and extent of deuteration. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity (by HPLC), isotopic enrichment, and residual solvent content is supplied with each order to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.