Description

(5S)-4-[(E)-Ethylidene]-1,3,4,5,6,7-Hexahydro-6-Hydroxymethyl-2α,5-Ethano-2H-Azocino[4,3-B]Indole-6β-Carboxylic Acid Methyl Ester is a complex, high-purity indole alkaloid derivative with a unique bridged azocine structure. This compound is a critical advanced pharmaceutical intermediate valued for its stereochemical complexity and functional group diversity, enabling the synthesis of sophisticated active pharmaceutical ingredients (APIs). It is primarily sought by pharmaceutical R&D and manufacturing organizations engaged in the development of novel therapeutic agents, particularly within specialized neurological and oncological research.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the total synthesis of complex natural products and novel drug candidates.
• Neurological Research: Used in the research and development of compounds targeting specific neurological pathways and receptors.
• Oncological Drug Discovery: Employed as a scaffold for developing potential anti-cancer agents due to its intricate molecular architecture.
• Asymmetric Synthesis: Utilized in stereoselective synthesis processes to construct chiral centers with high enantiomeric purity.
• Medicinal Chemistry Research: Acts as a versatile precursor for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry Development: Used in scaling up synthetic routes for potential commercial drug manufacturing.

Basic Information

Product Name	(5S)-4-[(E)-Ethylidene]-1,3,4,5,6,7-Hexahydro-6-Hydroxymethyl-2α,5-Ethano-2H-Azocino[4,3-B]Indole-6β-Carboxylic Acid Methyl Ester
CAS No.	3368-87-4
Molecular Formula	C20H24N2O4
Molecular Weight	356.42 g/mol
Synonyms	Methyl (5S)-4-[(E)-ethylidene]-1,3,4,5,6,7-hexahydro-6-(hydroxymethyl)-2α,5-ethano-2H-azocino[4,3-b]indole-6β-carboxylate; Tabersonine derivative; 19-Epivoacangine derivative; 6β-Hydroxymethyl-6β-carbomethoxy-4-ethylidene-2α,5-ethano-1,3,4,5,6,7-hexahydro-2H-azocino[4,3-b]indole; 3368-87-4; Voacanga alkaloid intermediate
EINECS	Contact for details

Quality Control

Our (5S)-4-[(E)-Ethylidene]-1,3,4,5,6,7-Hexahydro-6-Hydroxymethyl-2α,5-Ethano-2H-Azocino[4,3-B]Indole-6β-Carboxylic Acid Methyl Ester is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, NMR for structural confirmation, and MS for identity verification. We provide detailed Certificates of Analysis (COA) to ensure traceability and compliance with your GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). For long-term storage, consider storage under inert atmosphere to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.