Description

1-Bromo-2-Butyne is a versatile alkyne building block and alkylating agent, essential for advanced organic synthesis. Its high reactivity, particularly in Sonogashira coupling and nucleophilic substitution reactions, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing acetylene or bromoalkyne moieties.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators requiring specific alkyne functional groups.
• Material Science: Serves as a monomer or cross-linking agent in the development of specialty polymers, conductive materials, and liquid crystals.
• Organic Synthesis Reagent: Employed in Sonogashira cross-coupling reactions to form carbon-carbon bonds and in nucleophilic substitution reactions to introduce the butynyl group.
• Chemical Research: A valuable tool in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.
• Ligand & Catalyst Preparation: Used to synthesize specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	1-Bromo-2-Butyne
CAS No.	3355-28-0
Molecular Formula	C₄H₅Br
Molecular Weight	132.99 g/mol
Synonyms	2-Butyn-1-yl Bromide; 2-Butynyl Bromide; Bromomethylacetylene; 1-Bromo-2-butyne; 3-Butyn-1-yl Bromide; Bromo-2-butyne
EINECS	222-125-6

Quality Control

Our 1-Bromo-2-Butyne is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, NMR, and titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, bases, and oxidizing agents. Recommended storage temperature is 2-8°C for extended stability. Keep container tightly sealed when not in use to prevent moisture ingress and volatility loss.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Density (at 20°C)	1.40 - 1.45 g/mL
Refractive Index (n20/D)	1.480 - 1.490
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.