Description

1-Chloro-4-Methoxyisoquinoline is a versatile heterocyclic building block of significant interest in advanced organic synthesis. Its unique molecular scaffold, featuring both chloro and methoxy substituents, makes it a critical intermediate for constructing complex pharmacophores and functional materials. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic research.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, leveraging its heterocyclic structure for biological activity.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or charge-transport materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Catalyst Ligand Development: The isoquinoline core can be modified to create novel ligands for asymmetric catalysis and transition metal complexes.
• Custom Synthesis & Contract Manufacturing: A high-value starting material for custom synthesis projects and scale-up production under cGMP or ISO standards.

Basic Information

Product Name	1-Chloro-4-Methoxyisoquinoline
CAS No.	3336-60-5
Molecular Formula	C₁₀H₈ClNO
Molecular Weight	193.63 g/mol
Synonyms	4-Methoxy-1-chloroisoquinoline; 1-Chloro-4-methoxy-isoquinoline; Isoquinoline, 1-chloro-4-methoxy-; 1-Chloro-4-methoxy-2-azanaphthalene; 3336-60-5; 4-Methoxy-1-chloro-isoquinoline; 1-Chloro-4-methoxyisoquinoline; 1-Chloro-4-methoxy-isoquinoline
EINECS	Contact for details

Quality Control

Our 1-Chloro-4-Methoxyisoquinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades, including research and GMP grades, are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.